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Breast Cancer Outcomes Poorer In African American Women

Researchers found African American women with estrogen-receptor positive (ER+) breast cancer generally had poorer outcomes than European Americans. The research team believes the disparity is related to survival mechanism within the cancer cells, Georgetown University Medical Center reported. Breast tumors in African American women proved to be more resistant to tamoxifen, a leading cancer treatment that increases the activation of the “unfolded protein response” (UPR). If UPI is activated within a cancer cell due to cancer treatment it can switch on a pro-survival pathway that keeps the cancer alive. Read more…

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